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Analogs of Naprosyn.

Naprosyn is NSAID used to reduce intense pain caused by different kinds of arthritis.

Other names for this medication: Adin, Aflamax, Aflaxil, Alacetan, Alidase, Aliviomas, Alpoxen, Ameproxen, Anaflex, Anapran, Anaprox, Antalgin, Apo-napro-na, Apo-naproxen, Apo-naproxeno, Apraljin, Apranax, Apraxin, Aprol, Apromed, Apron-f, Apronax, Aprowell, Aproxil, Armanaks, Arnex, Artagen, Assonax, Atac, Atren, Boloxen, Bonmin, Bonyl, Brixonax, Bruproxen, Celonax, Colfem, Congex, Coniprox, Crysanal, Cudeprox, Dafloxen, Debril, Denaxpren, Desinflam, Deucoval, Diferbest, Difortan, Diproxen, Dolaxen, Dolofen, Dolomes, Dolormin, Doprox, Dysmenalgit, Ec-naprosyn, Emox, Emoxen, Eox, Equiproxen, Eurogesic, Fabralgina, Fadalivio, Febrax, Femme, Flanax, Flaxvan, Flogen, Floginax, Flogotone, Fluconazinn, Gerinap, Gynestrel, Inflamax, Inveoxel, Inza, Iraxen, Karoksen, Laser, Lexinax, Lundiran, Mafidol compuesto, Maxiflam, Mednap, Melgar, Merck-naproxen, Messelxen, Miranax, Mobilat, Momen, Momendol, Monarit, Monochroton, Nafasol, Naflapen, Naixan, Naksetol, Naledyn, Nalgesin, Napflam, Napium, Napmel, Naponal, Naposin, Napoxpharma, Napradol, Napratec, Naprelan, Napren, Naprius, Napro, Napro itedal, Napro-a, Naprobene, Naprocet, Naprocid, Naprodev, Naprofidex, Naproflam, Naprogen, Naprogesic, Naproksen, Napromed, Naprometin, Napromex, Naprontag, Naprorex, Naproson, Naprosyne, Naprovite, Naprox, Naprox-c, Naproxennatrium, Naproxeno, Naproxenum, Naproxi, Naprozen, Naprux, Naprux gesic, Napsod, Napsyn, Napton, Narocin, Naton, Natrax, Naxdom, Naxen, Naxin, Naxo, Naxyn, Neoeblimon, Neoflam, Neoprox, Nervogesic, Neuralprona, Nitens, Noflam, Noflam-n, Nopain, Novaxen, Novo-naprox, Novo-naprox sodium, Noxen, Nu-naprox, Nuprafen, Nurolasts, Nycopren, Odontogesic, Opraks, Pabi-naproxen, Painflex, Paraflaxan, Pms-naproxen, Point, Prevacid naprapac, Prexan, Priaxen, Prodexin, Pronaxen, Pronaxil, Pronol, Proxagol, Proxen, Proxidol, Releve, Reuxen, Saprox, Seladin, Servinaprox, Sindolan, Soden, Sonafalm, Sonap, Soproxen, Supofebril, Synalgo, Synax, Syndol, Synflex, Tacron, Tandax, Tarproxen, Ticoflex, Treximet, Triox, Tundra, Uniflam, Uninapro, Vimovo, Xenapro, Xenifar, Xenobid, Xpro.

Product Description

Naprosyn sodium belongs to a class of non-steroidal anti-inflammatory drugs (NSAIDs). This medication is used to reduce intense pain, inflammation and stiffness caused by conditions like osteoarthritis, rheumatoid arthritis, psoriatic arthritis, etc. It can be also applied in other cases.

Dosage and direction

Take Naprosyn by mouth with a glass of water, with or without food. Avoid cutting, crushing or chewing this medicine.

Do not take the medicine more often than it is prescribed. Do not give up taking it except on the advice of your doctor.

It may need time for the medicine to help.

Consult your doctor concerning proper dose for you.


Before taking Naprosyn tell your doctor or chemist if you are allergic to it; or if you have other allergies.

Naproxen, like other NSAIDs, can inhibit the excretion of sodium and lithium. Be cautious when using this drug along with lithium supplements.

Avoid drinking alcohol and smoking while being treated with this medication.

Aged people can be more sensitive to side effects of the medicine.

During pregnancy this treatment should be used only when strongly necessary.

As this medicament can be absorbed by skin, women who are pregnant or may become pregnant should not manipulate this medicine.


NaprosyN should not be used by patients with sodium-sensitive hypertension as well as by patients having demonstrated a reaction of hypersensitivity to it.

Possible side effect

The most common side effects are dry mouth, dizziness, irritability, sedation, insomnia, urinary retention, etc.

A very serious allergic reaction rarely occurs. Many people using this medicine do not have serious side effects.

Turn to your doctor or pharmacist for more details.

In case you notice the effects not listed here, contact your doctor or pharmacist.

Drug interaction

Tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use before using this medication.

Naprosyn can interact with:

_ NSAIDs of the salicylate family (Aspirin)

_ anticoagulants.

Turn to your doctor or pharmacist for more details.

Missed dose

If you have missed your dose, take it as soon as you remember. If you see that it is near the time for the next dose, skip the missed dose and resume your usual dosing schedule. Do not take your dose twice.


If you think you have used too much of this medicine seek emergency medical attention right away. The symptoms of overdose usually include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.


Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store your drugs in the bathroom. Keep all drugs away from reach of children and pets.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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Active Ingredient: Clindamycin.

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Analogs of Cleocin Gel: Cleocin.

Clindamycin is an active substance that is part of some medications from the group of semi-synthetic antibiotics of the linkosamine series. Drugs with the same name are available in different forms. So often mistakenly called a gel, clindamycin in which acts as an active substance. Before using medicines containing the clindamycin component, a doctor’s consultation and a detailed familiarization with the instructions for use are necessary.

1 Existing release forms and composition
2 Which gels include
3 Pharmacological action
3.1 Pharmacokinetics
4 Indications for use of clindamycin
5 Contraindications
6 How to use clindamycin
6.1 With diabetes
7 Side effects of clindamycin
7.1 From the side of musculoskeletal and connective tissue
7.2 Gastrointestinal tract
7.3 Hematopoietic organs
7.4 From the cardiovascular system
7.5 Allergies
7.6 Impact on the ability to control mechanisms
8 Special instructions
8.1 In old age
8.2 Children
8.3 During pregnancy and lactation
9 Overdose
10 Interactions with other drugs
10.1 Alcohol compatibility
11 Analogs
12 Pharmacy leave conditions
12.1 Can I buy without a prescription
12.2 Price
13 Storage conditions for the drug
13.1 Expiration date
15 Reviews of doctors and patients

1 Existing release forms and composition.

Clindamycin is available in the following forms:

  • Vaginal cream: supplied to medical facilities in a tube with applicators. The composition includes the previously mentioned active component in the form of phosphate and recipients: castor oil, propylene glycol, sodium benzoate, polyethylene oxide-1500, emulsifier No. 1. The ointment has a specific smell and has a white or cream-white color.
  • Gelatin capsules: sold in 16 pieces. In a pack and have a purple case with a red lid. The composition of the medication includes the active substance hydrochloride and additional ingredients: magnesium cit rate, lactose mono hydrate, talc, corn starch.
  • Glass ampules with a clear or yellowish solution for injection (i / m and i / v): packaged in plastic packaging and then in cardboard packs (10 pieces each). The composition of the drug contains an active substance.
  • Vaginal suppositories: available in cell packs (3 candles), placed in a cardboard box. The medication has a cylindrical shape and a white or white with a yellowish tint color.

The gel containing the substance clindamycin has different names and is supplied to medical institutions in aluminum tubes of 15 or 30 g. The maximum concentration of the component in question for external use reaches 1%.

2 Which gels include

Clindamycin is part of the following gels:

  • Adapalene;
  • Dalacin;
  • Copper Wedge;
  • Klintzitop;
  • clindoxyl;
  • Klindatsit B prolong;
  • clindacin;
  • Cleocin T;
  • Klindovit;
  • Klenzit-S.

3 Pharmacological action

When exposed to the body, clindamycin acts as a bacteriostatic. The component inhibits protein synthesis and interacts with infectious and parasitic microorganisms: anaerobic and microaerophilic gram-positive cocci (Clostridium tetani, Mycoplasma SPP.), Staphylococcus, bacilli and many strains of Clostridium perfringens.

3.1 Pharmacokinetics

The absorption of the named ingredient occurs in a short time, after which clindamycin enters the tissues and body fluids.
The maximum saturation of the component in the blood with oral use is observed within 1 hour, with intramuscular injection — after 1 hour in an adult and after 3 hours in a child.
The gel is applied externally, so if it gets into the mouth or eyes, thorough washing with a large amount of water is necessary.
In the case of intravenous administration, the highest concentration is noted at the end of the infusion. The substance is delayed in blood plasma for 8-12 hours, with a half-life of 2-2.5 hours. The components of the drugs are metabolized in the liver, and within 4 days are excreted from the body through the intestines and kidneys.

4 Indications for use of clindamycin

Clindamycin Medicines with the content in question – substances are prescribed in the following conditions:

  • infection of ENT organs — otitis media, pharyngitis, tonsillitis;
  • damage to bones and joints — osteomyelitis, arthritis;
  • infection in the respiratory system — inflammation of the pleural sheets, purulent-destructive limited process in the lungs, bronchitis, pneumonia;
  • purulent wounds and infections of soft tissues and epidermis — acne, acute inflammation of the cell space, furunculosis, purulent lesion of the fingers and / or feet, erysipelas;
  • damage to the abdominal organs — peritonitis, abscesses;
  • gynecological diseases — colpitis, salpingitis, chlamydia, adnexitis, endometritis, malignant neoplasms.

5 Contraindications

Contraindications for the use of bacteriostatic drugs include:

  • individual intolerance to one or more components;
  • liver or kidney dysfunction;
  • bronchial asthma;
  • ulcer, ulcerative colitis;
  • autoimmune disease that affects neuromuscular synapses;
  • age up to 1 month;
  • elderly age;
  • pregnancy and lactation period (except for external use).

6 How to use clindamycin

The gel containing the ingredient of the same name is applied in a thin layer on acne and acne areas, after cleansing the skin. The dosage of capsules for adults and children over 15 years of age is prescribed by a medical specialist.

Recommended treatment: 1 PC. 4 times a day or 2-3 tablets in several doses (in the presence of severe infections). In / m and in / in the introduction: adults: 300 mg 2 times a day or 1.2-2.7 g per day (depending on the patient’s condition); children over 3 years: 15-25 mg (or 25-40 mg) per kilogram. The full dose is used in 3-4 doses.

Intravaginal administration of suppositories should be made 1 time per day before bedtime.

6.1 With diabetes

Antibiotics for diabetes are prescribed after the necessary medical examinations. Dosage depends on the general condition of the patient and the individual characteristics of his body.

7 Side effects of clindamycin

It is not excluded the development of negative reactions from the body.

7.1 From the side of musculoskeletal and connective tissue

The appearance of systematic back pain.

7.2 Gastrointestinal tract

From the digestive system in some patients, the following side effects are noted:

  • nausea and vomiting;
  • diarrhea and abdominal discomfort;
  • pricks;
  • metallic taste (after iv administration of high doses of the drug);
  • inflammation of the mucous membrane of the esophagus (when using capsules);
  • hyperbilirubinemia;
  • increased activity of hepatic enzymes and bilirubin in blood plasma;
  • disturbances in the functioning of the liver and jaundice (rarely).

From the digestive system, some patients experience nausea and vomiting.

7.3 Hematopoietic organs

In rare cases, there is a decrease in the number of leukocytes, neutrophilic granulocytes and platelets in the blood.

7.4 From the cardiovascular system

With rapid intravenous administration of the drug, blood pressure may decrease, weakness and dizziness appear.

7.5 Allergies

Possible allergic reactions include:

  • urticaria;
  • anaphylactic shock;
  • fever
  • Quincke’s edema;
  • inflammation of the skin and mucous membranes (in isolated cases);
  • erythema multiforme;
  • anaphylactic shock (rarely).
    When using the gel, contact dermatitis and systemic side effects may develop. In the case of intravaginal administration, adverse reactions from the sensory organs are found: dizziness, vertigo.

7.6 Impact on the ability to control mechanisms

With the regular manifestation of side effects in the form of vomiting, allergic reactions, dizziness, or a decrease in blood pressure, it is recommended to abandon driving during treatment.

8 Special instructions

The gel containing the active ingredient is not recommended to be applied to the skin after using scrubs, as this will lead to severe skin irritation. Patients who have diseases of the gastrointestinal tract should be careful when using capsules. In case of diarrhea or the manifestation of symptoms of colitis during the course of therapy, you should consult your doctor.

Patients who have diseases of the gastrointestinal tract should be careful when using capsules.

9 Overdose

In case of excessive use of the active ingredient, it is possible to increase side effects, for the elimination of which symptomatic therapy is prescribed.

10 Interactions with other drugs

The substance enhances the effect of medicines that are used to relax skeletal muscles. Synergism is observed while taking the active ingredient with metronidazole, ceftazidime and ciprofloxacin.
Synergism is observed while taking the active ingredient with metronidazole. Joint use with opioids can lead to inhibition of respiratory function, and with sympathomimetics, macrolides and chloramphenicol, to a mutually competing effect. The active ingredient minimizes the effectiveness of aminoglycosides.

10.1 Alcohol compatibility

The combination of antibiotics and alcohol is unacceptable.

11 Analogs


12 Pharmacy leave conditions

Preparations containing the active ingredient in question are prescription.

12.1 Can I buy without a prescription

There are cases of the sale of medicines without a doctor’s prescription. However, self-medication can lead to negative consequences.

12.2 Price

The cost of the gel, which includes the active component, varies from 20gm × 2 creams $ 44.57 to $ 77.37. depending on the manufacturer and place of sale.

13 Storage conditions for the drug

Medicines should be kept out of the reach of young family members. Recommended air temperature is +15 … + 25 ° C.

13.1 Expiration date

The injection and vaginal ointment can be used within 2 years from the date of manufacture by the manufacturer. Capsules, suppositories and gel with the active ingredient – 3 years.

15 Reviews of doctors and patients

  • I prescribe a drug for the treatment of bacterial vaginosis in women and anaerobic balanitis in men. The medication is effective for erythrasma.
  • She took clindamycin to prevent inflammation during dental treatment. The result is excellent. No side effects were observed.

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Cialis Daily, known as a weekend pill, is one of the most effective solutions for patients with erectile dysfunction. Effective and long action of the drug makes it possible to maintain stable and long erection, treat premature ejaculation and other dysfunctions. Cialis Daily is one of the best-selling medicines in the world today.

Dosage and direction
Usual dose is one 20 mg Cialis Daily tablet. It’s enough to give you confidence in sexual activity. However, for treatment of pulmonary arterial hypertension the dose can be increased up to 40 mg per day. To enjoy sex and reliable erection, you only have to take one Cialis tablet an hour before the beginning of sexual activity. Its action can last up to 36 hours.

Carefully read the instructions before taking Cialis Daily. Consultation with a doctor is not necessary, but we strongly recommend you to talk to a medical specialist to find out if you are allergic to the drug component or take any incompatible medicines.

Allergy to any of the drug’s components makes its use impossible. Hypotension (low blood pressure) is also a contraindication. Cialis Daily should be used carefully and never overdosed.

Possible side effect
Possible adverse effects of Cialis Daily are dizziness, headaches, back pain, runny nose and indigestion. Patients with individual intolerance to the drug may also experience flushes, muscle aches and vision impairment.

Drug interaction
Tadalafil, the active component of Cialis Daily, interacts with organic nitrates. It cause in severe blood pressure drop, which is dangerous. Hepatic CYP3A4 enzyme inducers can shorten the effect of Cialis.

Missed dose
In case you have missed the dose of Cialis Daily, take it as soon as you remember. Note, that you should not take more than one prescribed dose of the drug once daily. Do not take more than a prescribed dose within 24 hours.

Overdose of Cialis Daily can lead to blood pressure drop, hypotension, dizziness, severe headaches and other unwanted problems. Never overdose the medication, but if you did, immediately contact the medical care specialist for instructions.

Store Cialis Daily in a dark place at room temperatures. Do not give the medication to children. Do not expose the drug to heat and direct sunlight.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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👍 Analogs of Cleocin: Cleocin Gel.

Other names for this medication:

Acnestop, Agis, Aknet, Aknezel k,  Albiotin, Anerocid,  Aniclindan,  Antirobe, Arfarel, Bactemicina, Basocin, Benzolac cl,  Bexon,  Bioclindax,  Biodaclin, Biodasin, Borophen, Botamycin-n, Candid-cl, Clamine-t,  Clendix, Cleorobe, Clidacin, Clidacin-t,  Clidamacin, Clidan, Clidets,  Climadan, Climadan acne, Clin, Clin-sanorania,  Clinacin, Clinacnyl,  Clinamicina, Clinaram, Clinbercin, Clinda, Clinda mip, Clinda-derm,  Clinda-ipp, Clinda-saar, Clinda-t,  Clindabeta, Clindabuc, Clindacin,  Clindacne, Clindacutin, Clindacyl, Clindacyn, Clindagel, Clindahexal,  Clindal,  Clindalind, Clindamax, Clindamek, Clindamicin,  Clindamicina,  Clindamycine, Clindamycinum, Clindamyl, Clindana, Clindanil,  Clindareach,  Clindasol, Clindasome, Clindastad, Clindaval,  Clindess,  Clindesse,  Clindets, Clindexcin, Clindobion, Clindopax, Clindoral,  Clindox,  Clinex, Clinfol, Clinidac, Clinika, Clinimycin, Clinium, Clinmas, Clinsol,  Clintabs, Clintopic, Clinwas, Cliofar, Cliz, Cluvax, Comdasin, Cutaclin,  Dacin, Daclin, Dalacin, Dalacine, Dalagis t,  Dalcap, Damiciclin, Damicine,  Damiclin, Dentomycin, Derma, Dermabel, Divanon, Edason, Eficline, Ethidan, Euroclin, Evoclin, Fouch, Handaramin, Indanox, Jutaclin, Klamoxyl,  Klimicin, Klin-amsa, Klindacin, Klindagol, Klindamicin,  Klindamycin,  Klindan, Klindaver, Klinoksin, Klitopsin, Lanacine, Lexis, Lindacil,  Lindacyn, Lindan, Lindasol, Lintacin s,  Lisiken, Luoqing,  Medacin,  Mediklin, Meneklin, Midocin, Milorin, Myclin, Naxoclinda, Niladacin,  Nufaclind, Opiclam, Panancocin s,  Paradis, Permycin, Prolic, Ribomin,  Rosil, Sobelin, Sotomycin, Tidact, Toliken, Topicil, Torgyn, Trexen,  Turimycin, Upderm, Veldom, Velkaderm, Ygielle, Z-clindacin,  Ziana, Zindaclin, Zindacline, Zumatic.

Indications for use
Bacterial infections caused by susceptible microorganisms: infections of upper respiratory tract infections (including tonsillitis, pharyngitis, sinusitis, otitis media); respiratory tract infections (bronchitis, pneumonia, lung abscess, pleural empyema, fibrosing alveolitis); infections of bones and joints (osteomyelitis, septic arthritis); purulent infections of the skin and soft tissues (including acne, boils, cellulitis, impetigo, felon, infected wounds, abscesses, erysipelas); sepsis (primarily anaerobic); infections of the pelvic organs and intra-abdominal infections (including peritonitis, abscesses of the abdominal organs, subject to the simultaneous use of drugs active against gram-negative aerobic microbes); gynecological diseases (endometritis, adnexitis, colpitis, abscess of the fallopian tubes and ovaries, salpingitis, pelvioperitonitis); infections of the oral cavity (including periodontal abscess); toxoplasma encephalitis, malaria (caused by Plasmodium falciparum), pneumonia (caused by Pneumocystis carinii), sepsis; endocarditis, chlamydia; scarlet fever; diphtheria.

Hypersensitivity, child age (up to 1 month) .C caution. Myasthenia gravis, bronchial asthma, ulcerative colitis (in history), severe renal and / or liver failure, pregnancy, lactation.

Pharmachologic effect
An antibiotic group of lincosamides. It has a broad spectrum of activity, bacteriostatic, binds to the 50S subunit of the ribosomal membrane and inhibits protein synthesis in the microbial cell. In respect of a number of gram-positive cocci possible bactericidal action. Active against Staphylococcus spp. (including Staphylococcus epidermidis producing penicillinase), Streptococcus spp. (excluding Enterococcus spp.), Streptococcus pneumoniae, Corynebacterium diphtheriae, spore-and non-spore-forming anaerobes, and microaerophilic gram-positive cocci (including Peptococcus spp. and Peptostreptococcus spp.), Clostridium perfringens, octrathrystheros, optus, optus, and optics, and Peptostreptococcus spp. (including Bacteroides fragilis and Prevotella melaninogenica), Fusobacterium spp., Propionibacterium spp., Eubacter spp., Actinomyces spp.

Most of the strains of Clostridium perfringens are sensitive to the drug, however, since other types of clostridia (Clostridium sporogenes, Clostridium tertium) are resistant to the action of the drug, the definition of an antibioticogram is recommended for infections caused by Clostridium spp.

It is clinically ineffective against Mycoplasma pneumoniae, Haemophilus influenzae, Helibacter pylori, Neisseria meningitidis, Neisseria gonorrhoeae, Ureaplasma urealyticum.

There is cross-resistance between the drug and lincomycin. Effective in the treatment of asymptomatic diphtheria carrier (weekly course of treatment, oral).

Side effects
On the part of the nervous system: rarely – a violation of neuromuscular conduction.

On the part of the digestive system: abdominal pain, nausea, diarrhea, vomiting, esophagitis, pseudomembranous enterocolitis, hepatotoxicity, hyperbilirubinemia, jaundice, dysbacteriosis.

From the side of blood-forming organs: leukopenia, neutropenia, agranulocytosis, thrombocytopenia.

From the side of the cardiovascular system: with a quick i.v. administration – a decrease in blood pressure, up to collapse.

Allergic reactions: rarely – maculopapular rash, urticaria, itching; in some cases, exfoliative and vesicular-dermatitis, eosinophilia, anaphylactoid reactions.

Local reactions: pain (at the site of the / m injection), thrombophlebitis (at the place of / in the injection).

Other: development of superinfection.

Special instructions
Pseudomembranous colitis can appear both on the background of the drug intake, and 2-3 weeks after stopping the treatment (3-15% of cases); manifested by diarrhea, leukocytosis, fever, pain in the abdomen (sometimes accompanied by the release of blood and mucus from the stool). If these phenomena occur in mild cases, it is enough to cancel the treatment and use of ion exchange resins (Kolestiramine, Kolestipol), in severe cases, it is shown to compensate for the loss of fluid, electrolytes and protein, the appointment of vancomycin 125-500 mg 4 times / day, or bacitracin 25 Thousands of units 4 times a day for 7-10 days, or metronidazole 500 mg 3 times a day. You can not use drugs that inhibit intestinal peristalsis.

The safety of the drug in newborns has not been established. The solution contains benzyl alcohol, which can lead to the development of asphyxiation syndrome in premature babies. According to “vital” indications, newborns are prescribed in a dose of 15-20 mg / kg / day in 3-4 doses, in some cases a smaller dose may be effective.

With long-term treatment of children requires periodic monitoring of blood counts and the functional state of the liver.

When prescribing the drug in high doses, it is necessary to control the concentration of the drug in the plasma.

It should not be prescribed for the treatment of meningitis.

Rapid i.v. administration can lead to the development of acute LV failure and a decrease in blood pressure.

Incompatible with solutions containing a complex of vitamins of group B, aminoglycosides, ampicillin, phenytoin, barbiturates, aminophylline, calcium gluconate and magnesium sulfate.

Taking the drug shows antagonism with erythromycin and chloramphenicol.

Strengthens the action of competitive muscle relaxants.

With simultaneous use with opioid (narcotic) analgesics, it is possible to increase the respiratory depression they cause (up to apnea).

The simultaneous appointment with antidiarrheal drugs that reduce gastrointestinal motility, increases the risk of pseudomembranous colitis.

Aminoglycosides expand the spectrum of antimicrobial action; enhances (mutually) the effect of rifampicin.

Cleocin Gel prescribed for the treatment of juvenile acne and other conditions. Cleocin Gel is used for treating severe acne.

Below is a list of possible side effects that can be caused by the elements that make up Cleocin Gel. This list is not final. These side effects have been reported previously, but not always fixed when using the drug. Some of these side effects can be extremely rare, but have incredibly serious consequences. If you experience any side effects, contact your healthcare professional immediately. Especially in the case of observing side effects for a long time.
– Burning
– Itchy
– Dryness
– Redness
– Oily skin
– Skin peeling
If you encounter side effects that are not listed above, contact your doctor for advice. In addition, you can report side effects to the local Food and Drug Administration.

Precautionary measures
Before you start taking this drug, tell your doctor about medicines already used, nutritional supplements (for example, vitamins, natural supplements, etc.), allergic reactions, existing diseases, and current health status (for example, pregnancy, impending surgery, etc.). Side effects of the drug may be more pronounced in a certain state of your body. Take the drug as directed by your doctor or follow the instructions for use that came with the drug. The dosage of the drug depends on your condition. Notify your doctor about the absence of changes or worsening of your condition. Important points to discuss with your doctor are listed below.
Pregnant women planning to become pregnant or breastfeeding
Children under the age of 12.

If you take other drugs or supplements at the same time as this drug, the effectiveness of Cleocin Gel may change. Tell your health care provider about all the drugs, vitamins, and nutritional supplements that you use. Your doctor will be able to make a correct plan for taking the drug, which will avoid negative interactions.

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Active Ingredient: Cabergoline.

Analogs of Dostinex: Cabgolin.

Other names for this medication:
Actualene, Agalates, Cabaser, Cabaseril, Cabergolek, Cabergolin, Cabergolina, Cabergolinum, Caberlin, Caberpar, Cabeser, Cabest, Cieldom, Galastop, Kabergolin, Lac stop, Lactamax, Lactovet, Prolastat, Sogilen, Sostilar, Triaspar.

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Pharmachologic effect

Dopamine receptor agonist. Cabergoline is a dopaminergic ergoline derivative, characterized by a pronounced and prolonged prolactin-lowering effect. The mechanism of action is associated with direct stimulation of the dopamine D2 receptors of the lactotropic pituitary cells. In doses exceeding those to reduce the level of prolactin in the blood plasma, it has a central dopaminergic effect due to the stimulation of dopamine D2 receptors.

A decrease in the concentration of prolactin in the blood plasma is noted 3 hours after taking the drug and persists for 7-28 days in healthy volunteers and patients with hyperprolactinemia, and up to 14-21 days in women in the postpartum period. Prolactin-reducing action is dose-dependent both in terms of severity and duration of action.

Cabergoline has a strictly selective effect, does not affect the basal secretion of other pituitary and cortisol hormones.

Pharmacological effects of cabergoline, not related to the therapeutic effect, include only a decrease in blood pressure. With a single use of the drug, the maximum hypotensive effect is observed during the first 6 hours and is dose-dependent.


٭Suction and distribution

After oral administration, cabergoline is rapidly absorbed from the gastrointestinal tract. Cmax in plasma is achieved in 0.5-4 hours. Binding to plasma proteins is 41-42%. Css is achieved after 4 weeks of therapy due to prolonged T1 / 2.

Meal does not affect the absorption and distribution of cabergoline.


The main product of cabergoline metabolism identified in the urine is 6-allyl-8β-carboxy-ergoline at a concentration of up to 4-6% of the dose taken. The content in the urine of 3 additional metabolites does not exceed 3% of the dose. Metabolism products have a significantly lower effect in suppressing the secretion of prolactin compared to cabergoline.


T1 / 2, estimated by the rate of excretion by the kidneys, is 63-68 h in healthy volunteers and 79-115 h in patients with hyperprolactinemia.

10 days after taking the drug, 18% and 72% of the received dose are detected in the urine and feces, respectively, and the proportion of unchanged cabergoline in the urine is 2-3%.

☞prevention of physiological postpartum lactation;

☞suppression of established postpartum lactation;

☞treatment of disorders associated with hyperprolactinemia, including amenorrhea, oligomenorrhea, anovulation and galactorrhea;

☞prolactin-secreting pituitary adenomas (micro- and macroprolactinomas), idiopathic hyperprolactinemia, “empty” Turkish saddle syndrome in combination with hyperprolactinemia.

Dosing regimen📅
Is ingested, during meals.

Lactation prevention: 1 mg (2 tab.) Once on the first day after birth.

Suppression of established lactation: 0.25 mg (1/2 tab.) 2 times / day every 12 hours for 2 days (total dose is 1 mg). In order to reduce the risk of orthostatic hypotension in lactating mothers, a single dose of Dostinex should not exceed 0.25 mg.

Treatment of disorders associated with hyperprolactinemia: the recommended initial dose is 0.5 mg per week in 1 (1 tab.) Or 2 doses (1/2 tab., For example, on Monday and Thursday). Increasing the weekly dose should be carried out gradually – at 0.5 mg with an interval of 1 month to achieve the optimal therapeutic effect. The therapeutic dose is usually 1 mg per week, but can range from 0.25 mg to 2 mg per week. The maximum dose for patients with hyperprolactinemia is 4.5 mg per week.

Depending on tolerance, the weekly dose can be taken once or divided into 2 or more doses per week. The division of the weekly dose into several doses is recommended when prescribing the drug in a dose of more than 1 mg per week.

In patients with hypersensitivity to dopaminergic drugs, the likelihood of side effects can be reduced by starting Dostinex therapy at a lower dose (0.25 mg 1 time per week), followed by a gradual increase until the therapeutic dose is reached. To improve the tolerability of the drug in the event of severe side effects, a temporary dose reduction is possible, followed by a gradual increase, for example, by 0.25 mg per week every 2 weeks.

Side effect
In clinical studies using Dostinex to prevent physiological lactation (1 mg once) and to suppress lactation (0.25 mg every 12 hours for 2 days), approximately 14% of women had adverse reactions. When using Dostinex for 6 months at a dose of 1-2 mg per week, divided into 2 doses, for the treatment of disorders associated with hyperprolactinemia, the incidence of adverse reactions was 68%. Adverse reactions occurred mainly during the first 2 weeks of therapy and in most cases disappeared as therapy continued or several days after discontinuation of the drug Dostinex. Adverse reactions were usually transient, mild or moderate in severity and dose-dependent. At least once during the course of therapy, severe side effects were observed in 14% of patients; due to adverse reactions, treatment was discontinued in approximately 3% of patients.

The most frequent adverse reactions are presented below.

☁Since the cardiovascular system: heartbeat; rarely, orthostatic hypotension (with prolonged use, the drug has a hypotensive effect); asymptomatic decrease in blood pressure during the first 3-4 days after birth (systolic – more than 20 mm Hg, diastolic – more than 10 mm Hg).

☁Nervous system disorders: dizziness / vertigo, headache, fatigue, drowsiness, depression, asthenia, paresthesias, syncope, nervousness, anxiety, insomnia, impaired concentration.

☁On the part of the digestive system: nausea, vomiting, epigastric pain, abdominal pain, constipation, gastritis, dyspepsia, dryness of the oral mucosa, diarrhea, flatulence, toothache, sensation of irritation of the pharyngeal mucosa.

☁Other: mastodynia, nasal bleeding, flushing to the skin of the face, transient hemianopia, vascular spasms of the fingers, muscle cramps of the lower extremities (like other ergot derivatives, Dostinex may have a vasoconstrictor effect), blurred vision, flu-like symptoms, malaise, periorbital and peripheral swelling, anorexia, acne, pruritus, joint pain.

🌞With long-term therapy with the use of the drug Dostinex, deviation from the norm of standard laboratory parameters was rarely observed; in women with amenorrhea, a decrease in hemoglobin level was observed during the first few months after the recovery of menstruation.🌞

☁The following adverse reactions associated with the use of cabergoline were registered in the post-marketing study: alopecia, increased blood CPK activity, mania, dyspnea, edema, fibrosis, abnormal liver function, abnormal liver function, hypersensitivity, rash, respiratory disorders, respiratory failure, valvulopathy, pathological addiction to gambling, hypersexuality, increased libido, aggressiveness, psychotic disorders, pericarditis, bouts of sudden sleep, decrease or increase in body weight, nasal congestion.

🍓Hypersensitivity to cabergoline or other components of the drug, as well as to any ergot alkaloids;

🍓dysfunction of the heart and respiration due to fibrous changes or the presence of such conditions in history;

🍓during long-term therapy: anatomical signs of valvular pathology of the heart (such as thickening of the valve leaflet, narrowing of the valve lumen, mixed pathology of narrowing and stenosis of the valve), confirmed by echocardiography (EchoCG), conducted before the start of therapy;

🍓lactose intolerance, lactase deficiency, glucose-galactose malabsorption;

🍓children and adolescents under 16 years of age (safety and efficacy have not been established).

Dostinex should be administered with caution in the following conditions and / or diseases:

🍓arterial hypertension that developed during pregnancy, for example, preeclampsia or postpartum arterial hypertension (Dostinex is prescribed only in cases where the potential benefit from the use of the drug significantly exceeds the possible risk);

🍓severe cardiovascular diseases, Raynaud’s syndrome;

🍓peptic ulcer, gastrointestinal bleeding;

🍓severe liver failure (the use of lower doses is recommended);

🍓severe psychotic or cognitive impairment (including in history);

🍓simultaneous use with drugs that have a hypotensive effect (due to the risk of orthostatic hypotension).

Use during pregnancy and lactation
Since there have been no controlled clinical trials with the use of the drug Dostinex in pregnant women, the prescription of the drug during pregnancy is possible only in cases of emergency, when the expected benefit to the mother outweighs the potential risk to the fetus.

If pregnancy has occurred on the background of treatment with Dostinex, the feasibility of discontinuing the drug should be considered, also taking into account the benefit / risk ratio.

According to available data, the use of Dostinex in a dose of 0.5-2 mg per week for disorders associated with hyperprolactinemia was not accompanied by an increase in the frequency of miscarriages, premature birth, multiple pregnancy and congenital malformations.

There is no information about the release of the drug in breast milk, however, in the absence of the effect of using the drug Dostinex to prevent or suppress lactation, breastfeeding should be abandoned. For disorders associated with hyperprolactinemia, Dostinex should not be prescribed to mothers who do not want to stop lactation.

Application for violations of the liver
With caution, use the drug in severe liver failure (lower doses are recommended).

Use in children
Contraindications: children and adolescents under 16 years of age (safety and efficacy have not been established).

Special instructions
Before prescribing Dostinex for the purpose of treating disorders associated with hyperprolactinemia, it is necessary to conduct a full study of the function of the pituitary gland.

In addition, the state of the cardiovascular system, including echocardiography, should be assessed in order to detect valvular dysfunction asymptomatic.

As with the use of other ergot derivatives, pleural effusion / pleural fibrosis and valvulopathy were observed in patients after long-term administration of cabergoline. In some cases, patients received prior therapy with dopamine ergotonin agonists. Therefore, Dostinex should not be used in patients with existing signs and / or clinical symptoms of dysfunction of the heart or respiration associated with fibrotic changes or with such a history. The drug should be discontinued if there are signs of the appearance or worsening of blood regurgitation, narrowing of the lumen of the valves or thickening of the valve leaflets.

It was found that ESR increases with the development of pleural effusion or fibrosis. If an unexplained increase in ESR is detected, a chest X-ray is recommended. A study of the concentration of creatinine in the blood plasma and an assessment of renal function can also help in the diagnosis. After discontinuation of Dostinex in patients with pleural effusion / pleural fibrosis or valvulopathy, symptoms improved.

It is not known whether cabergoline can worsen the condition of patients with signs of blood regurgitation. Cabergoline should not be used in the detection of fibrous lesions of the valvular apparatus of the heart.

Fibrotic disorders can develop asymptomatically. In this regard, the condition of patients receiving long-term treatment with cabergoline should be regularly monitored and special attention should be paid to the following symptoms:

☞pleural-pulmonary disorders: such as shortness of breath, difficulty breathing, persistent cough or chest pain;

☞renal failure or obstruction of the vessels of the ureters or abdominal organs, which may be accompanied by pain in the side or lumbar region and edema of the lower extremities, any swelling or tenderness in the abdominal region, which may indicate the development of retroperitoneal fibrosis;

☞pericardial fibrosis and fibrosis of the valves of the heart often manifest heart failure. In this regard, it is necessary to exclude fibrosis of the valves of the heart (and constrictive pericarditis) at the onset of symptoms of heart failure.

It should regularly monitor the patient’s condition for the development of fibrotic disorders. The first time EchoCG should be performed 3-6 months after the start of therapy. Then this study should be conducted depending on the clinical assessment of the patient’s condition, paying particular attention to the symptoms described above, at least every 6-12 months of therapy.

The need for other monitoring methods (for example, physical examination, including auscultation of the heart, radiography, computed tomography) is assessed individually for each patient.

With increasing doses, patients should be under the supervision of a physician in order to establish the minimum effective dose that provides a therapeutic effect.

After an effective dosing regimen is selected, it is recommended to regularly (once a month) determine the serum prolactin concentration. Normalization of prolactin concentration is usually observed within 2-4 weeks of treatment.

After discontinuation of Dostinex, there is usually a relapse of hyperprolactinemia, however, in some patients persistent inhibition of prolactin concentration is observed for several months. In most women, ovulatory cycles persist for at least 6 months after discontinuation of Dostinex.

Dostinex restores ovulation and fertility in women with hyperprolactinemic hypogonadism. Since pregnancy can occur before menstruation is restored, it is recommended that pregnancy tests be performed at least once every 4 weeks during the amenorrhea period, and after menstruation is restored – every time there is a delay in menstruation for more than 3 days. Women who want to avoid pregnancy should use barrier methods of contraception during treatment with Dostinex, as well as after discontinuation of the drug before repeating anovulation. Women who have become pregnant should be supervised by a physician in order to identify the symptoms of an increase in the pituitary gland in a timely manner, since an increase in the size of existing pituitary tumors is possible during pregnancy.

Dostinex should be administered in lower doses to patients with severe hepatic insufficiency (Child-Pugh class C), who have been given prolonged therapy with the drug. With a single dose of 1 mg in these patients, an increase in AUC was observed compared with healthy volunteers and patients with less severe hepatic insufficiency.

The use of cabergoline causes drowsiness. In patients with Parkinson’s disease, the use of dopamine receptor agonists can cause sudden sleep. In such cases, it is recommended to reduce the dose of the drug Dostinex or discontinue therapy.

Studies on the use of the drug in elderly patients with disorders associated with hyperprolactinemia, was not conducted.

Use in Pediatrics

The safety and efficacy of the drug in children and adolescents under 16 years of age has not been established.

Influence on ability to drive motor transport and control mechanisms

Patients taking the drug Dostinex should refrain from driving vehicles and mechanisms and other potentially dangerous activities requiring concentration of attention and speed of psychomotor reactions.


Symptoms (more likely, symptoms of dopamine receptor hyperstimulation): nausea, vomiting, dyspeptic symptoms, orthostatic hypotension, confusion, psychosis, hallucinations.

Treatment: should carry out activities aimed at removing the drug (gastric lavage) and to maintain blood pressure. The use of dopamine antagonists is recommended.

Drug interaction

Information about the interaction of cabergoline and other ergot alkaloids is absent, therefore the simultaneous use of these drugs during long-term therapy with Dostinex is not recommended.

Since cabergoline has a therapeutic effect by direct stimulation of dopamine receptors, the drug cannot be administered simultaneously with drugs acting as dopamine antagonists (including phenothiazines, butyrophenones, thioxanthenes, metoclopramide), because they can weaken the effect of cabergoline, aimed at reducing the concentration of prolactin.

Like other ergot derivatives, cabergoline cannot be used simultaneously with macrolide antibiotics (for example, with erythromycin), since this can lead to an increase in the system bioavailability of cabergoline.

Terms and conditions of storage
The drug should be stored out of reach of children at a temperature not exceeding 25 ° C. Shelf life – 2 years.

Pharmacy sales terms
The drug is available without a prescription.

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AnalogsOf Arimidex: Clomid, Estrace, Premarin, Dostinex, Ortho Tri-Cyclen, Aygestin, Plan B, Ponstel, Parlodel, Fosamax.

Active Ingredient: Anastrozole.

Arimidex is used for treating breast cancer in women who have been through menopause, including women with disease progression after tamoxifen therapy. ⇜

Other names for this medication:
Anastrol, Anastrozolo, Anastrozolum, Armidex.

Clinico-pharmacological group
Antitumor drug. Aromatase Inhibitor.

Pharmachologic effect
Highly selective nonsteroidal aromatase inhibitor. Aromatase is an enzyme with which in postmenopausal women, androstenedione in peripheral tissues is converted into estrone and then into estradiol. Reducing circulating estradiol has a therapeutic effect in patients with breast cancer. In postmenopausal medication in a daily dose of 1 mg causes a decrease in estradiol levels by 80%.

Arimidex does not possess progestogenic, androgenic and estrogenic activity.

Arimidex in a daily dose of up to 10 mg has no effect on the secretion of cortisol and aldosterone (therefore, the use of the drug does not require the replacement of corticosteroids).


After oral administration, anastrozole is rapidly absorbed from the gastrointestinal tract. Cmax in plasma is reached within 2 hours (on an empty stomach). Food somewhat reduces the rate, but not the degree of absorption. Small changes in the rate of absorption do not lead to a clinically significant effect on the Css of the drug in plasma with a daily intake of 1 tab. Arimidex.

Anastrozole is associated with plasma proteins by 40%. Approximately 90-95% of Сss is achieved after 7 days of taking the drug. There is no information about the cumulation of the drug and the dependence of the pharmacokinetic parameters of anastrozole on time and dose.

Anastrozole is metabolized by N-dealkylation, hydroxylation and glucuronization. Triazole, the major metabolite detected in plasma, does not inhibit aromatase.

Anastrozole is displayed slowly, T1 / 2 – 40-50 h.

Anastrozole and its metabolites are excreted mainly with urine (less than 10% of the excreted dose – unchanged), within 72 hours after taking the drug.

Pharmacokinetics in special clinical situations

The determined clearance of anastrozole after oral administration in volunteers with stabilized liver cirrhosis or renal dysfunction does not differ from clearance determined in healthy volunteers.

Anastrozole pharmacokinetics does not depend on age in postmenopausal women.

☞adjuvant therapy for early hormone-positive breast cancer in postmenopausal women;

☞treatment of advanced breast cancer in postmenopausal women;

☞adjuvant therapy for early hormone-positive breast cancer in postmenopausal women after tamoxifen therapy for 2–3 years.


☞renal failure severe (creatinine clearance less than 20 ml / min);

☞moderate and severe liver failure (safety and efficacy not established);

☞concomitant therapy with tamoxifen;

☞children’s age (safety and efficacy not established);


☞lactation (breastfeeding);

☞Hypersensitivity to anastrozole and other components of the drug.

The drug is not prescribed to women in premenopausal women.

Adults, including elderly patients, the drug is prescribed 1 mg orally 1 time / day, long-term. If there is evidence of disease progression, the drug should be discontinued. As adjuvant therapy, the recommended duration of treatment is 5 years.

Patients with mild and moderately severe renal impairment do not require dose adjustment.

Patients with mild hepatic impairment do not require dose adjustment.

The tablet should be swallowed whole and washed down with water. It is recommended to take the drug at the same time of day.

Side effects
👣 Determination of the frequency of adverse reactions: very often (> 10%); often (1-10%); rarely (0.1-1%); very rarely (<0.1%).

👣 Since the cardiovascular system: very often – tides.

👣 From the musculoskeletal system: often – arthralgia.

👣 Reproductive system: often – vaginal dryness; rarely, vaginal bleeding (mainly during the first weeks after the cancellation or change of previous hormonal therapy with Arimidex).

👣 On the part of the digestive system: often – nausea, diarrhea; rarely – anorexia, vomiting, increased activity of GGT and alkaline phosphatase.

👣 On the part of the nervous system: often – headache, carpal tunnel syndrome (mainly observed in patients with risk factors for this disease); rarely – drowsiness.

👣 Metabolism: rarely – hypercholesterolemia. The drug may cause a decrease in bone mineral density due to a decrease in circulating estradiol, thereby increasing the risk of osteoporosis and bone fractures.

👣 Dermatological reactions: often – thinning hair, skin rash; very rarely – erythema multiforme (Stevens-Johnson syndrome).

👣 Allergic reactions: very rarely – angioedema, urticaria, anaphylactic shock.

👣 Other: often – asthenia.

Single clinical cases of drug overdose are described. A single dose of Arimidex, at which life-threatening symptoms develop, has not been established.

Treatment: there is no specific antidote. If necessary, carry out symptomatic therapy: induction of vomiting (if the patient is conscious), general supportive therapy, monitoring the patient and monitoring the function of vital organs and systems. Dialysis is possible.

Drug interaction
Clinical studies on drug interactions with antipyrine and cimetidine indicate that co-administration of Arimidex with other drugs is unlikely to lead to a clinically significant interaction due to cytochrome P450.

There is no clinically significant drug interaction when taking Arimidex at the same time as other frequently prescribed drugs.

At the moment there is no information on the use of Arimidex in combination with other anticancer drugs.

Estrogen containing preparations should not be administered concurrently with Arimidex, since they reduce the pharmacological effect of the latter.

Tamoxifen should not be given at the same time as Arimidex, since it may weaken the pharmacological action of the latter.

Special instructions
In women with a receptor-negative estrogen tumor, the efficacy of Arimidex has not been demonstrated, unless there was a prior positive clinical response to tamoxifen.

In case of doubts about the hormonal status of the patient, the menopause must be confirmed by determining the sex hormones in the blood serum.

There are no data on the safety of Arimidex in patients with severe liver dysfunction or in patients with severe renal insufficiency (CC less than 20 ml / min).

In case of persistent uterine bleeding while receiving Arimidex, consultation and supervision of a gynecologist is necessary.

Drugs containing estrogen should not be administered simultaneously with Arimidex.

By lowering the level of circulating estradiol, Arimidex can cause a decrease in bone mineral density.

In patients with osteoporosis or with the risk of osteoporosis, bone mineral density should be assessed by means of densimetry (for example, DEXA scan) at the beginning of treatment and over time. If necessary, treatment or prevention of osteoporosis should be initiated under the close supervision of a physician.

There is no data on the simultaneous use of anastrozole and preparations of GnRH analogues.

It is not known whether anastrozole improves the results of treatment when used in combination with chemotherapy.

Safety data for long-term treatment with anastrozole has not yet been obtained.

With the use of Arimidex, ischemic diseases were observed more frequently than with tamoxifen therapy, but no statistical significance was noted.

The efficacy and safety of Arimidex and tamoxifen, when applied simultaneously, regardless of the status of hormone receptors, are comparable to those of tamoxifen alone. The exact mechanism of this phenomenon is not yet known.

Use in Pediatrics

Safety and efficacy of the drug in children have not been established.

Influence on ability to drive motor transport and control mechanisms

Some side effects of Arimidex, such as asthenia and drowsiness, may adversely affect the ability to perform work that requires increased concentration of attention and quickness of psychomotor reactions. In this regard, it is recommended that when these symptoms appear, caution should be exercised when driving a car or moving machinery.

Pregnancy and lactation
The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

Use in childhood
The drug is contraindicated for use in children (safety and efficacy not established).

In case of impaired renal function
Patients with mild and moderately severe renal impairment do not require dose adjustment.

Contraindicated in severe renal failure (creatinine clearance less than 20 ml / min).

With abnormal liver function
Patients with mild hepatic impairment do not require dose adjustment.

Contraindicated in moderate or severe liver failure (safety and efficacy not established).

Pharmacy sales terms
The drug is available without a prescription.

Terms and conditions of storage
The drug should be stored out of reach of children at a temperature not exceeding 30 ° C. Shelf life – 5 years.

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Active Ingredient: Disulfiram.

Analogs Of Antabuse : Lioresal, Aricept, Combivent, Dramamine, Sinemet, Differin, Lamictal, Diamox, Betapace, Prograf, Alfacip.

Other names for this medication:

Alcophobin, Anticol, Aversan, Diabuse, Disulfiramo, Disulfiramum, Disulphiram, Esperal, Etabus, Etiltox, Refusal, Tenutex.

In 1 tablet of disulfiram 200 mg (400 mg).

Corn starch, povidone, sodium bicarbonate, talc, silicon dioxide, tartaric acid, magnesium stearate, MCC, – as auxiliary substances.

Pharmachologic effect

Pharmacodynamics and pharmacokinetics

Inhibits acetaldehyde dehydrogenase, which is involved in the metabolism of ethyl alcohol. The delay in the oxidation of ethyl alcohol at the stage of acetaldehyde causes its accumulation and the development of intoxication – a disulfiram-alcohol reaction, which is accompanied by severe sensations and violent vegetative reactions: pulsating headache, noise in the head, tachycardia, a decrease in blood pressure, heartbeat, blurred vision, nausea, vomiting .
Discomfort associated with alcohol intake, lead to a conditioned reflex aversion of alcoholic beverages.


Absorbed 70–90% after ingestion. It is well soluble in lipids and accumulates in fat depots. It is rapidly metabolized, and as a result, during a series of transformations, it is converted into an active metabolite, methyl diethylthiocarbamic acid ester (methyl DTK). The maximum concentration of which in the blood is determined after 4 hours, however, activity towards acetaldehyde dehydrogenase is noted after 3 days of regular administration.

T1 / 2 methyl-DTC – 10 h, but the activity with respect to aldehyde dehydrogenase lasts longer. Therefore, after drug withdrawal, the effect will remain 7-14 days. Metabolites are excreted in the urine, partly with exhaled air, and 20% of unchanged disulfiram through the intestine.

Indications for use
Antabuse is used to prevent recurrence in the treatment of chronic alcoholism and alcohol dependence.


Absolute contraindications:
– neuritis of the auditory and optic nerve;

– diseases of the cardiovascular system (marked cardiosclerosis, post-infarction conditions, cerebral arteriosclerosis, aortic aneurysm, hypertension);

– polyneuritis of any origin;

– emphysema, bronchial asthma;
pulmonary tuberculosis;

– mental illness, epilepsy and epileptiform syndrome;

– severe hepatic and renal failure;

– thyrotoxicosis;

– diseases of the blood-forming organs;

– aggravation of peptic ulcer disease;

– malignant tumors;

– pregnancy;

– hypersensitivity.

Other cardiovascular diseases, over 60 years of age, peptic ulcer in remission, consequences of strokes with residual effects, history of antabuse psychoses, are relative contraindications.

Side effects

Antabuse can cause the following reactions due to the action of disulfiram:
– hepatitis;

– metallic taste in the mouth;

– polyneuritis of the lower extremities;

– memory loss, headaches;

– asthenia;

– optic neuritis;

– skin manifestations.

Reactions due to the joint intake of disulfiram and alcohol:

– respiratory failure;

– heart rhythm disorders;

– myocardial infarction, angina;

– cardiovascular collapse;

– swelling of the brain;

– thrombosis of cerebral vessels;

– psychosis.

Instructions for use Antabuse (method and dosage)
Tablets are taken orally, dissolved in 0.5 cups of water. Take 200–500 mg 1–2 times a day, prescribed by a doctor. A week later, a disulfiram-alcohol sample is taken — in parallel with taking 500 mg of Antabuse, the patient drinks 20–30 ml of vodka. Observe the reaction of the body, and with a weak reaction, the dose of alcohol is increased by 20 ml. The sample is repeated several times, while adjusting the dose of alcohol and the drug. In the future, apply a maintenance dose of 200 mg / sutot 1 year to 3 years.

Instructions for use Antabuse contains warnings that the drug is prescribed after the examination and the mandatory warning of the patient about complications. With prolonged therapy may develop psychosis, thrombosis of cerebral vessels, acute polyneuritis.

An overdose of disulfiram increases the severity of reactions and leads to depression of the nervous system (coma), the development of neurological and cardiovascular complications. Symptomatic therapy is carried out.

An unacceptable combination is the intake of alcoholic beverages, alcohol-containing drugs and products, since an intolerance reaction occurs.

Metronidazole, Tinidazole, Ordinazole, Secnidazole, while taking it with Antabuse, cause delirious disorders and disorders of consciousness.

When taken with phenytoin, a significant rise in its plasma level occurs with the development of toxic symptoms.

The anti-tuberculosis drug Isoniazid may cause poor coordination.

Antabuse increases the effect of oral anticoagulants (Warfarin), and therefore there is a risk of bleeding.

Disulfiram inhibits the metabolism of Theophylline, so its dose should be reduced.

Potentiates the sedative effect of benzodiazepines (Chlordiazepoxide and Diazepam), the dosage of which should be reduced.

Storage conditions
At a temperature not exceeding 30 ° C.

Shelf life
5 years.

Antabuse Reviews
Anti-recurrent and supportive treatment of alcoholism is carried out by drugs: Disulfiram, Naltrexone and Acamprosate. The innovative form of disulfiram is “effervescent” Antabus tablets, which dissolve in water, have no taste or smell. When taken together with alcohol, the drug causes unpleasant (aversive), painful sensations: fear of death, shortness of breath, feeling of lack of air and so on. The fear of death – the main manifestation of the action of disulfiram – forces the alcoholic to stop drinking alcohol.

Reviews of doctors boil down to a warning about serious complications of disulfiram-alcohol reaction. Given this and a large number of contraindications, the drug is prescribed only by a doctor, and the treatment should be under the supervision of a narcologist. It is impossible to carry out treatment independently in secret from the patient, since the phenomena caused by the preparation can be so pronounced that reanimation measures will be required. The patient should be informed that drinking a small dose of alcohol while taking Antabuse can be fatal. Before the appointment of the drug to conduct an examination and the patient must confirm that he wants to get rid of alcoholism.

Doctors remind that, unfortunately, there are no sufficiently effective medicines that suppress the craving for ethyl alcohol. And this method is not a treatment, but a “prohibitive method”, so that the patient does not have a path to retreat, and has the opportunity to achieve stable remission. Treatment of alcoholism should be comprehensive (psychological assistance, acupuncture, sedatives and a great desire to stop drinking). And reviews about the Antabuse – proof of this. Many patients took it for several years, but the craving for alcohol persisted, and only the fear of physical pain and death restrained them.

“I took it 5 years ago under the control of a narcologist and a psychologist. I was torn off several times, but now I can control myself – the psychologist helps ”

“There was always a craving for alcohol, but Antabus always restrained me and stopped me.”

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Other Names Of Levitra: Vardenafilum,Vivanza.

Analogs of Levitra.

Active Ingredient: Vardenafil.

Levitra Professional is a drug for the treatment of male dysfunction, allowing to normalize and maintain an erection during the entire sexual intercourse. The action of the drug is based on an increase in blood flow to the genital organ, however, the desired effect occurs only with sexual arousal.

Levitra Professional is a drug for the treatment of male dysfunction, allowing to normalize and maintain an erection during the entire sexual intercourse. The action of the drug is based on an increase in blood flow to the genital organ, however, the desired effect occurs only with sexual arousal. A man feels a tremendous surge of strength and energy, receives from intimate closeness better and more lasting sensations.

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Levitra Professional instruction.

The optimal daily dosage is 2.5 to 20 mg, individually administered to each patient, taking into account the characteristics of the organism and the degree of impairment of potency. Do not exceed the rate recommended by the doctor. Also, be sure to warn the doctor if you regularly take any medications or dietary supplements.

To use the drug should be 20-30 minutes before intimacy. With sublingual administration, the active components of the agent enter the body, bypassing the gastrointestinal tract, therefore Levitra Professional can be taken even on a full stomach. The effect of the agent lasts for 8-12 hours. Possible side effects: facial flushing, indigestion, headache.

They will help to decide whether to buy Levitra Professional, reviews of users who successfully use this tool and were able to get the desired effect. Before using the drug should always consult a doctor. This is especially true of persons suffering from cardiovascular, liver and kidney diseases, and pathologies caused by bleeding disorders.

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Action time: up to 8 hours
The onset of effect: in 25-30 minutes
Packing quantity: 10 tablets.
Active ingredient: vardenafil
Manufacturer: India
Amount of active substance: 20 mg.
Taste: bitter

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Diclofenac Gel is used to treat joint pain and pills Diclofenac order online at low cost

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Active Ingredient: Diclofenac

Analogs Of Diclofenac Gel: Voltaren.

Clinical and pharmacological group.
NSAIDs for external use

Pharmachologic effect
NSAIDs for external use.

Diclofenac has pronounced analgesic and anti-inflammatory properties. By indiscriminately inhibiting the enzymes of COX-1 and COX-2, it breaks the metabolism of arachidonic acid and the synthesis of prostaglandins, which are the main link in the development of inflammation.

Used to eliminate the pain syndrome and reduce the swelling associated with the inflammatory process. When topical application causes weakening or disappearance of pain in joints at rest and during movement. Reduces the morning stiffness and swelling of the joints, contributes to an increase in the volume of movements.

With the recommended method of applying the drug, no more than 6% of diclofenac is absorbed.

↬ Post-traumatic inflammation of soft tissues and joints due to stretching, overstrain and bruises;

↬ rheumatic diseases of soft tissues (including tendovaginitis, bursitis, lesion of periarticular tissues);

↬ Pain syndrome and puffiness associated with diseases of muscles and joints (including rheumatoid arthritis, osteoarthritis, radiculitis, lumbago, sciatica);

↬ muscular pain of rheumatic and non-rheumatic origin (for a 5% gel).

↬ violation of the integrity of the skin;

↬ indication in an anamnesis for seizures of bronchial asthma after application of NSAIDs and salicylates (including acetylsalicylic acid);

↬ III trimester of pregnancy;

↬ lactation period;

↬ children’s age till 6 years;

↬ hypersensitivity to diclofenac or other components of the drug;

↬ Hypersensitivity to salicylates (including to acetylsalicylic acid) or other NSAIDs.

With caution should be used in patients with hepatic porphyria (exacerbation), erosive and ulcerative lesions of the gastrointestinal tract, severe violations of liver and kidney function, chronic heart failure, bronchial asthma, in the first and second trimesters of pregnancy, in elderly patients.

Additionally for the preparation in the form of a gel 5%: with caution should be used for violations of blood clotting (including hemophilia, lengthening bleeding time, a tendency to bleeding).

Outwardly. The amount of the drug depends on the size of the painful area. A single dose of 1% gel is 2-4 g (comparable in volume to the size of a cherry or walnut). A single dose of the gel is 5% – up to 2 g (about 4 cm with the tube open completely open).

Adults and children over the age of 12 years, the drug should be applied to the skin 3-4 times / day and lightly rub.

For children aged 6 to 12 years, the preparation in the form of a gel 1% should be applied to the skin no more than 2 g (per application) up to 2 times / day; the preparation in the form of a gel 5% – no more than 1 g (about 2 cm with a fully open neck of the tube) for one application up to 2 times / day.

After applying the product, the hands should be washed.

The duration of treatment depends on the indications and the effect observed. After 2 weeks of use, consult a physician.

Side effects
Local reactions: eczema, photosensitivity, contact dermatitis (itching, redness, swelling of the treated area of ​​the skin, papules, vesicles, peeling).

Systemic reactions: generalized skin rash, allergic reactions (hives, angioedema, bronchospastic reactions), photosensitization.

Extremely low systemic absorption of active components of the drug with external application makes an overdose almost impossible.

Symptoms: with the accidental ingestion of large amounts of gel (more than 20 g), there may be systemic adverse reactions that are characteristic of NSAIDs.

Treatment: should wash the stomach, take activated charcoal.

Drug Interactions
The drug may enhance the effect of drugs that cause photosensitivity.

Clinically significant interaction with other drugs has not been described.

Special instructions
The gel should only be applied to intact skin, avoiding contact with open wounds.

After applying, do not apply an occlusive dressing.

Do not allow the product to get into the eyes and mucous membranes.

With prolonged use of large amounts of the drug, it is impossible to exclude the occurrence of systemic side effects, characteristic for NSAIDs.

Pregnancy and lactemia
Contraindicated use of the drug in the III trimester of pregnancy. Use in I and II trimesters is possible only after consultation with a doctor.

Experience in using the drug during lactation is not available.

Application in childhood
Contraindicated in children under 6 years.

In case of violations of kidney function
With caution should apply the drug in severe violations of kidney function.

With violations of liver function
With caution should be used in patients with hepatic porphyria, severe violations of liver function.

Conditions of leave from pharmacies
The drug is approved for use as a means of OTC.

Terms and conditions of storage
The drug should be stored in a dry place inaccessible to children at a temperature of 15 ° to 25 ° C; Do not freeze. Shelf life – 2 years.

Other names for this medication:

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Other names for this medication :
Aciban-dsr, Adzole-dm, Agilam, Apentral, Apuldon, Arcelenan, Atidon,  Avizol-d, Avomit, Benzilum, Bipéridys, Bompy, Canozol-d, Cilroton, Cinet,  Cobaperidon, Costi, Cosy, Coszol-d, Dalic, Dany, Deflux, Degut,  Depam,  Diocid-d, Docivin, Dolium, Dombaz, Domedon, Domepraz, Domerdon,  Dometa, Dometic, Domezol, Domilin, Domilux, Domin, Dominal, Dominat, Dompan, Domped, Dompel, Dompenyl, Domper, Domperdone,  Domperidona, Domperidoni maleas, Domperidonmaleat, Domperidonum.

Motilium – antiemetic drug, which is able to stimulate the motility of the gastrointestinal tract.

The drug for children and adults alleviates the condition with nausea, heartburn, vomiting, belching, bloating, heaviness in the stomach and excessive gas generation. When poisoning and the above conditions, Motilium restores disturbed processes and accelerates recovery.

Produced in the form of tablets, coated with a shell and suspension for oral administration. Before using the drug to treat children should consult a pediatrician, there are contraindications.

The active substance Motilium quickly absorbed and reaches the maximum presence in the blood plasma within an hour after taking the medication. Reduced acidity of the stomach worsens the absorption of the drug.

Domperidone does not accumulate in the body, is completely metabolized in the digestive tract and liver and is excreted with waste of vital activity. At oral intake with urine, up to 31% of domperidone is excreted, with feces – up to 66%. A small fraction of the substance is excreted from the body in its original form. Half-life in a healthy person is about 8 hours.

The study of distribution of the drug on experimental animals indicates a low penetration of domperidone into the brain. Data on the pharmacokinetics of the drug were obtained in the study of adult volunteers.

Indications for use
What helps? Motilium is used in diseases of the upper parts of the digestive tract, which reduce motor-evacuation functions.

Indications for use:

☛ abdominal pain;
☛ bloating;
☛ feeling of overfilling in epigastrium;
☛ heartburn, flatulence;
☛ frequent regurgitation, cyclic vomiting;
☛ nausea and vomiting caused by a violation of diet or drug therapy;
☛ disruption of the stomach in children;
☛ a complex of dyspeptic symptoms that are associated with a slowdown in gastric emptying.
Suspension is used for gastrointestinal reflux and regurgitation in newborns.

Use in pregnancy and lactation
Data on the use of Motilium during pregnancy is not enough.

To date, there is no evidence of an increased risk of human developmental malformations. Nevertheless, Motilium should be prescribed during pregnancy only in cases where the expected benefit of therapy for the mother exceeds the potential risk to the fetus.

In women, the concentration of domperidone in breast milk is 10-50% of the corresponding plasma concentration and does not exceed 10 ng / ml. The total amount of domperidone excreted into breast milk is less than 7 μg / day when the maximum permissible doses are applied. It is not known whether this level has a negative effect on newborns. Therefore, if you need to use the drug Motilium during lactation, breastfeeding should be discontinued.