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The Latin name of the substance: Clomiphenum(Clomipheni)

Chemical name: 2- [4- (2-Chloro-1,2-diphenyl) phenoxy] -N, N-diethylethanamine (as citrate)

Gross-formula: C26H28ClNO

Therapeutic substance Clomiphene
Estrogens, progestins; antagonists, and their homologs

The nosological classification (ICD-10)

  • E28.2 Syndrome of polycystic ovaries
  • N46 Male infertility
  • N91 lack of menstruation, scanty and rare menstruation
  • N93 Other abnormal bleeding from the uterus and vagina
  • N97 Female infertility
  • O92.6 galactorrhea

Code CAS
911-45-5

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Pharmacology
Mode of action – anti-estrogen.
It binds estrogen receptors in the hypothalamus and ovaries. If ingestion is well absorbed from the gastrointestinal tract. It is metabolized in the liver. Excreted in the bile, subjected to enterohepatic recirculation. Because the body is excreted in the faeces. T1 / 2 of 5-7 days. In small doses, it increases the secretion of gonadotropins (prolactin, FSH and LH) stimulates ovulation. At low levels of endogenous estrogens in the body has a mild estrogenic effect, at a high level – antiestrogen. By reducing the level of circulating estrogen, promotes the secretion of gonadotropins. In large doses slows secretion of gonadotropins. Progestogens, and androgen activity is not.

Application of the substance Clomiphene
Anovulatory infertility (ovulation induction), dysfunctional uterine bleeding, amenorrhea (disgonadotropnaya form secondary, postkontratseptivnaya), galactorrhea (on the background of the pituitary tumor), polycystic ovaries (Stein syndrome – Leventhal), Chiari-Frommelya syndrome, androgen deficiency, oligospermia, for diagnosis violations of gonadotropic pituitary function.

Contraindications
Hypersensitivity, severe liver and / or kidney failure, metrorrhagia of unknown etiology, ovarian cysts, pituitary tumor or failure, pregnancy (including suspected it).

Pregnancy and breast-feeding
Contraindicated during pregnancy.
Category effects on the fetus by FDA – X.

Side effects of substance Clomiphene
From the nervous system and sensory organs: headache, dizziness, depression, fatigue, anxiety, insomnia, slowing of mental and motor responses, impaired vision.

From the digestive tract: nausea, vomiting, gastralgia, flatulence, diarrhea.

With the genitourinary system: cystic enlargement of the ovaries, dysmenorrhea, pollakiuria, polyuria, multiple pregnancy.

Other: hot flashes, weight gain, pain in the abdomen, the chest, the testes (in men), hyperthermia, reversible hair loss, allergic skin reactions.

Interaction
Compatible with drugs gonadotropins.

Overdose
Symptoms: Nausea, vomiting, flushing, visual disturbances, pain in the abdomen.
Treatment: symptomatic therapy.

Dosing and Administration
Inside. To stimulate ovulation appoint 50 mg 1 time a day at bedtime, starting from 5th day of the menstrual cycle during 5 days (in the absence of the cycle – at any time); if there is no effect (ovulation does not occur within 30 days) increase the dose to 150 mg / day or lengthen the course to 10 days. Heading dose should not exceed 1 g of ovulation is determined by the presence of a biphasic basal body temperature, the average cyclical increase in production of LH, increase in serum progesterone during the luteal phase of the likely medium or menstruation women with amenorrhea. If ovulation has occurred and pregnancy has not occurred, it is necessary to repeat the course. If held after ovulation was no menstrual bleeding, you should take into account the possible pregnancy.

Men are not to treat oligospermia appoint 50 mg 1-2 times a day for 3-4 months (requires systematic monitoring spermiogram).

Precautions substance Clomiphene
Before and during treatment must be continued monitoring gynecologist should check ovarian function, vaginal exercise study to observe the phenomenon of “pupil” and others. With an increase in ovarian cystic transformation or clomiphene treatment suspended until the normalization of the size of the ovaries. The therapy continues with minimal doses or shorten the period of treatment. The treatment is recommended to monitor liver function. You can not assign an exemption from work to persons whose professional activity requires quick physical and mental reactions.

Doping Information
This drug is added to the list of banned doping agents. Detection time is 3-6 months, depending on the method of detection.

Clomid (clomiphene) or Nolvadex (tamoxifen), which is better?
In this article we will try to resolve doubts about the choice between the two drugs, as well as find the differences: Clomid and Nolvadex.
Clomiphene citrate (available in pharmacies under the brand names Clomid, Clomid) and tamoxifen (brand name Nolvadex) is an antiestrogen trifeniletilenov belonging to the same group. They are structurally similar and are classified as selective estrogen receptor modulators with mixed agonistic and antagonistic properties. This means that in certain tissue, they block the action of estrogen receptors by binding, while in other tissues could act as a real estrogen receptors activating. In men, both drugs act as anti-estrogens in their ability to interfere with estrogen negative feedback on the hypothalamus and stimulate the increased production of GnRH (gonadotropin-releasing hormone). This will result in increased production of luteinizing hormone by the pituitary gland, which in turn can increase the production of testosterone by the testes. This makes both drugs, but for some reason bodybuilders continue to think that only good for Clomid testosterone stimulation.
Studies conducted in the late ’70s in the University of Ghent in Belgium make clear the advantages of Nolvadex over Clomid to increase testosterone levels. Researchers have looked at the effect of Nolvadex and Clomid endocrine system healthy men, as well as those who have suffered a small amount of spermatozoids (oligospermia). also found that Nolvadex when used for 10 days at a dosage of 20mg per day increased testosterone in the serum 142% of the initial level that was comparable with the effect of Clomid 150mg per day over the same period of time (an increase in testosterone levels were slightly but not significantly greater with Clomid). We must remember that this is the effect of three 50mg tablets of Clomid. At about the same price 50mg Clomid and 20mg Nolvadex we can already see a difference in relation to the price / benefit result in Nolvadex.

Clomid (clomiphene) or Nolvadex (tamoxifen): differences
Clomid (Clomid) acts on the estrogen receptors in the pituitary and ovaries. By linking estrogen receptors in the pituitary gland, Clomid breaks a negative feedback mechanism, ie, if usually estrogen, acting on the pituitary gland, reduce the production of FSH and LH, when taking Clomid does not happen. Directly on blood levels of estrogen Clomid does not work.
Nolvadex (tamoxifen) also has no effect on estrogen levels, as its mechanism of action is also reduced to the estrogen receptor blockade, including the pituitary gland. However, Clomid is a more selective (selective) blocker and Nolvadex – less selective. If Clomid binds to estrogen receptors in the pituitary and preferably testes Nolvadex then contacting them almost in the entire organism. The exception is the bone where clomid and tamoxifen contrary to activate estrogen receptors.
Thus, Clomid acts as an estrogen antagonist and eliminates their inhibitory effect on the hypothalamus and pituitary gland, contributing to a more rapid recovery of their functions. Nolvadex blocks the receptors in almost all tissues and helps to ensure that the body began to rebuild its own testosterone. Importantly, Nolvadex capable of blocking estrogen receptors in the pituitary less than Clomid.
Clomiphene and tamoxifen did not affect the metabolism of estrogenic hormones, so the intake of estrogens these means continue to erode the liver enzymes, and do not accumulate in the body.

Nolvadex has drawbacks: quite toxic (sometimes it manifests itself loss of appetite and nausea, increased risk of thrombosis). Tamoxifen increases the amount of progesterone receptors, so it can not be used, if the rate is based on progestin drugs (nandrolone, trenbolone). In this case, you should use clomiphene.

Dosages clomiphene citrate determined depending on the degree of severity of the course. The more drugs were involved than in high dosages, and how these drugs were stronger, the longer you will need time to recover, and the greater the amount of Clomid need.

Overall, the scheme can be described as follows:
Very tough course – 3 * 150/12 * 100/15 * 50/15 * 25
Hard course – 15 * 100/15 * 50/15 * 25
The average rate – 30 * 50/15 * 25
Easy Course -15 * 50/15 * 25/15 * 25 (every 2 days)
Very easy course – 15 * 50/15 * 25
* Note – the first digit, the number of days, the second digit after the asterisk – dosage of clomiphene. For example, 15 * 50/15 * 25 means that the first 15 days is necessary to take 50 mg of Clomid, and then for the next 15 days – 25 mg.

Reviews of Clomid in bodybuilding
Any negative reviews on the use of Clomid in bodybuilding absent. Not surprisingly, since the side effects of the drug are absent (at least, not observed). Clomiphene citrate helps athletes recover quickly and incurring minimal losses after a course of steroids.

Question: What is Clomid?
Answer: This is a synthetic estrogen that is mostly prescribed by doctors to girls, to stimulate ovulation in women.
Question: Why do bodybuilders use it while Clomid?
Answer: As you know, all anabolic steroids lead to a reduction in endogenous secretion of testosterone by the body (yes, everything, even oxandrolone 20 mg for 4 weeks and your test with LH and FSH greatly reduced). After discontinuation of AAS endogenous testosterone at zero, and hormonal therapy is finished. It enters the body in the catabolic process. In turn, Clomid is used during this period to quickly lower stimulate FSH and LH and testosterone levels to raise usual. This will reduce the catabolism of the period for your body.

As a therapeutic drug Clomid for infertility have started to apply to the United States in the early 70s. Today it is already known around the world and is produced by pharmaceutical companies under the names Clomid, serofen, sepafar, omifin, pergotaym, gonafen, duinum, klostil, AYou and klostilbegit.

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Malegra – is a modern drug for treating erectile disorders and premature ejaculation. Due to the fact that the product has a similar structure and mechanism of action, it is an analogue of Viagra. Unlike the original, this means a low incidence of adverse reactions of the body and has fewer contraindications.
This favorable difference is made possible thanks to an improved drug formula and the presence of ancillary components, which soften the effects of the active substance sildenafil. Malegra shows men with poor potency, reduced sexual vigor and sexual dissatisfaction. The product is effective in normalizing the hormonal levels and increase testosterone levels. Already after the first dose, he prolongs sexual intercourse up to three times. Malegra can be taken occasionally to prolong sexual intercourse, or a course of treatment for a qualitative systematic premature ejaculation.

Malegra how the
The mode of action is to suppress Malegra ejaculation and increased blood flow to the pelvic organs. Due to the active ingredient drug relaxes the smooth muscles of the penis. This effect not only increases the flexibility and elasticity of body muscle tissue, making it more sensitive, but also provides a healthy blood circulation inside the genitals.
As a result of increased blood inflow erection in men is achieved much faster, it becomes stronger and persists for several hours. Slowing ejaculation occurs by blocking the action of the enzyme PDE-5, which is responsible for ejaculation and narrowing of the blood vessels of the penis. Thanks to the relaxing effect of the drug vessels to dilate, which promotes quality nutrition cavernous calf muscle and holding a long intercourse. Furthermore, the effect of sildenafil allows to obtain the necessary amount of oxygen.

Malegra reading
The main indication for the use of the drug Malegra is the presence of erectile dysfunction. This pathology manifests itself weak and short-lived erections, premature ejaculation, low sexual energy, the partial or complete absence of erection.
The last symptom is usually said about the threat of impotence, erectile disorders therefore should be of high quality, regular and long. Clinical trials have shown that the four-week course of treatment Malegroy significantly improves sexual health. After treatment, most patients feel a surge of vitality and energy, strengthening erections and increase the duration of intimacy.
Malegra no less effective for the treatment of prostatitis and infertility. In these diseases, the product can be used as an adjuvant. Malegra has an excellent protective effect. Its components have anti-viral and anti-microbial properties that restore the healthy microflora of the pelvic organs. In addition, the chronic administration of the product at the man there is an increase in testosterone levels and normalization of hormonal levels.

Malegra effect
Malegra prompt action and, at the same time, safe for the organism. The drug starts to work after only an hour after ingestion, and its effect lasts for six hours. Under the influence of money in men increased sexual experiences, sexual organ enhanced sensitivity and the erogenous zones, the penis increases of two to four centimeters, and the erection becomes more stable and long-term.
Increased testosterone that is seen with regular use of the product is due to the rupture of relations with hormone proteins. As a result, the level of free testosterone increases, and with increased potency and sexual activity with him. Malegra has a positive impact on the quality of reproductive function, increasing semen production and sperm increasing speed.

Malegra contraindications
Malegra has effective action and consists of a powerful selective agents. This tool has a number of contraindications, in which use of sildenafil may cause serious harm to the body. First of all, the drug is absolutely contraindicated with hypersensitivity to sildenafil. Using Malegry allergy to the active component may cause severe complications and in some cases death. Before taking this product it is necessary to exclude the presence of individual intolerance. Start using the medication is recommended with a minimum dose.
Malegra also contraindicated in severe heart disease, kidney and liver. The drug is dangerous for men with epilepsy. Contraindication is a medical condition in which a person is not recommended for sexual activity (eg, heart attack or stroke). Malegra can not be used for women, minors young people, young children and men over 65 years. Also contraindications include injury to the penis and the presence of inflammatory processes in the body.

Malegra intake with alcohol
Malegra drug is not compatible with alcohol. Ethanol reduces the level of efficiency of mineral trace elements. By its action in the body decreases the rate of absorption of the drug into the bloodstream. In addition, sildenafil increases the concentration of alcohol in plasma, which in turn can cause enhanced expression of adverse reactions and serious health problems. It should be understood that even a small dose of liquor in conjunction with Malegra may cause unexpected reaction of the body, poisoning and intoxication.

Malegra reception with fatty foods
Experts do not recommend to eat fatty foods during the period of treatment with drugs to increase potency and eliminate erectile dysfunction. Vegetable and animal fats prevent rapid absorption of useful trace elements into the bloodstream, resulting in product effect occurs much later than the expected time. In this case Malegra can not give a positive effect. In the treatment of erectile dysfunction with this drug the man recommended to eat light foods that are low or moderate in fat (30-35%).

Malegra side effects
Malegra cause side effects if you are hypersensitive to the active substance or an overdose. In such cases, a man may occur following adverse reactions of the body: headache, dizziness, temporary disruption of visual acuity, increased eye sensitivity to light, light rhinitis symptoms, nausea, vomiting, upset the gastrointestinal tract, increased body temperature, redness of the face and neck , tachycardia, spasms in the lumbar region.
These side effects are not a direct threat to the body. Almost 100% of the time they are within one or two hours, without the use of additional medication. When the manifestation of severe and prolonged adverse reactions person should seek medical care. At the hospital, the doctor will conduct a series of surveys and prescribe symptomatic therapy.

Malegra overdose
If overdose Malegra the man manifested reinforced side effects. Among the first symptoms of overdose include: severe headache beggars, nausea and vomiting, cutting pain in the eyes, increased body temperature and blood pressure, weakness. The drug at high doses is harmful to the body. Severe overdose can cause serious poisoning, in which should go to the hospital. With an overdose of selective inhibitors of patients compulsorily assigned stomach lavage with potassium permanganate.

Malegra interactions with other drugs
Malegra not compatible with a number of potent drugs. The drug should not be taken together with the nitrogen donators, inhibitors of other enzymes, nitrates all groups, medicines to treat HIV, antidepressants, amphetamines. In the treatment of substances which are not mentioned above, prior to use Malegra recommended to consult a specialist and undergo a medical examination. Admission Malegra incompatible drugs is dangerous not only to the emergence of adverse reactions, but serious complications. The product can be used in conjunction with vitamins, dietary supplements, mineral complexes.

Malegra Dosing and Administration
Malegra should be taken one hour before the start of sexual intimacy. The tablet or its part must be washed down with water or other liquid that does not contain alcohol. The maximum daily dose is 100 milligrams (one tablet). The manufacturer recommends taking the drug at a lower dose (50 mg).
Men are elderly, and patients with chronic diseases of the heart, blood vessels and liver should reduce the dose to a quarter of a tablet (25 mg). Malegra suitable for daily use. In the treatment of erectile disorder remedy can be used for three to four weeks. Before receiving read the instructions. Do not use the product after the expiration date. Keep it should be in a dry, dark and cool room at a temperature of 25 degrees Celsius.

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INSTRUCTIONS FOR USE PREPARATION SILDALIS with prices and reviews

Sildalis is used to treat sexual dysfunction in men. This is a unique combination drug that can restore potency and sex drive. The composition of the tablets is really unique, because there is no similar analogues in the components of the pharmaceutical market. Numerous reviews indicate its high efficiency.

Description
Sildalis available in tablet form for oral administration. Externally, the formulation is a tablet rectangular shape. The color is usually red. In the middle there is a dividing line, through which the tablet can be easily divided into two stages. Consisting of sildenafil and tadalafil. Instructions for use indicates that one tablet is chosen optimal therapeutic dose of both components, which is 100 mg and 20 mg, respectively.
Sildenafil and Tadalafil are a group of drugs – a fifth selective inhibitors of phosphodiesterase type, but each of them has specific characteristics with respect to the start and duration of action. In general, their effect is due to inhibition of the activity of this enzyme. As a result Sildalis causes vasodilation, in particular the corpora cavernosa of the penis. Enhancing blood flow and greater blood flow to the male genitals provide a full erection necessary for satisfactory sexual intercourse. The advantage of the preparation is that the two components potentiate each other’s effect. This fact is confirmed by many men reviews.

About the indications and contraindications
Instructions for use allocates some indications. Basically, they are all connected with the violation of erectile function. It should be noted that Sildalis demonstrates efficacy in reducing the potency of various origins. Also note reviews a positive effect on the libido and sexual desire. With regard to the contraindications, the instruction manual notes the following:
presence of congenital deformities and developmental abnormalities of the penis in men;
combination with medications containing nitrates;
the presence of liver disease and kidney disease, accompanied by severe disorders of functions;
an allergic reaction to the drug components;
diseases of the cardiovascular system.

Also it should be noted that the use of the drug in people older than 65 years may be accompanied by certain risks. Despite the fact that many of the responses deny the occurrence of side effects, the use of Sildalis funds for the elderly requires special attention. Since at this age, as a rule, there is a concomitant chronic pathology. And the action of the means to increase potency may cause its exacerbation or significant deterioration of health.
Side effects are not common, but about the likelihood of their occurrence should be remembered. Against the background of the use of funds can be a headache, a feeling of flushing, nasal congestion, dizziness, dyspepsia, allergic reactions and transient violation of color. If you still have any symptoms of the above, it is a chance to see a doctor. But the main thing – do not panic, because usually after the abolition of drugs such effects are alone.

How to use
Instructions for use not recommended to take more than one pill per day Sildalis funds. The best reception is a whole tablet or half an hour before intended sexual intercourse. The exact dose depends on the body’s needs. Importantly, the effect of the drug begins only if exciting factor. The duration of beneficial effect after administration of the tablet is up to 36 hours. During this period, a man capable of committing several sexual acts. At the same time period required for recovery after ejaculation significantly reduced over time, as evidenced by the reviews.
During the application Sildalis few simple rules must be observed. This will help reduce the likelihood of side effects and improve efficacy of the treatment of erectile dysfunction. So, against the backdrop of improving drug potency is recommended:
Do not take pills with fatty foods – is reduced drug efficacy.
– Can not be combined with alcohol – decreases the effectiveness of the drug, and can worsen the overall male body.
– The period between two doses of pills should not be less than 24 hours.

Сost of
To purchase a medicament for improvement of potency in the recipe is not necessary. However, before using it is better to consult a doctor. At a minimum, it is necessary to identify the root cause of erectile dysfunction, as well as to determine the presence or absence of indications to the use Sildalis.
The advantage is that there are several options for drug packaging date. Thus, if a suitable Sildalis, the packaging can be easily purchased from 12,18 or even 48 tablets. In this case, the price per pill is lower than the purchase of smaller size packages.

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