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Other names for this medication :
Aciban-dsr, Adzole-dm, Agilam, Apentral, Apuldon, Arcelenan, Atidon,  Avizol-d, Avomit, Benzilum, Bipéridys, Bompy, Canozol-d, Cilroton, Cinet,  Cobaperidon, Costi, Cosy, Coszol-d, Dalic, Dany, Deflux, Degut,  Depam,  Diocid-d, Docivin, Dolium, Dombaz, Domedon, Domepraz, Domerdon,  Dometa, Dometic, Domezol, Domilin, Domilux, Domin, Dominal, Dominat, Dompan, Domped, Dompel, Dompenyl, Domper, Domperdone,  Domperidona, Domperidoni maleas, Domperidonmaleat, Domperidonum.

Motilium – antiemetic drug, which is able to stimulate the motility of the gastrointestinal tract.

The drug for children and adults alleviates the condition with nausea, heartburn, vomiting, belching, bloating, heaviness in the stomach and excessive gas generation. When poisoning and the above conditions, Motilium restores disturbed processes and accelerates recovery.

Produced in the form of tablets, coated with a shell and suspension for oral administration. Before using the drug to treat children should consult a pediatrician, there are contraindications.

The active substance Motilium quickly absorbed and reaches the maximum presence in the blood plasma within an hour after taking the medication. Reduced acidity of the stomach worsens the absorption of the drug.

Domperidone does not accumulate in the body, is completely metabolized in the digestive tract and liver and is excreted with waste of vital activity. At oral intake with urine, up to 31% of domperidone is excreted, with feces – up to 66%. A small fraction of the substance is excreted from the body in its original form. Half-life in a healthy person is about 8 hours.

The study of distribution of the drug on experimental animals indicates a low penetration of domperidone into the brain. Data on the pharmacokinetics of the drug were obtained in the study of adult volunteers.

Indications for use
What helps? Motilium is used in diseases of the upper parts of the digestive tract, which reduce motor-evacuation functions.

Indications for use:

☛ abdominal pain;
☛ bloating;
☛ feeling of overfilling in epigastrium;
☛ heartburn, flatulence;
☛ frequent regurgitation, cyclic vomiting;
☛ nausea and vomiting caused by a violation of diet or drug therapy;
☛ disruption of the stomach in children;
☛ a complex of dyspeptic symptoms that are associated with a slowdown in gastric emptying.
Suspension is used for gastrointestinal reflux and regurgitation in newborns.

Use in pregnancy and lactation
Data on the use of Motilium during pregnancy is not enough.

To date, there is no evidence of an increased risk of human developmental malformations. Nevertheless, Motilium should be prescribed during pregnancy only in cases where the expected benefit of therapy for the mother exceeds the potential risk to the fetus.

In women, the concentration of domperidone in breast milk is 10-50% of the corresponding plasma concentration and does not exceed 10 ng / ml. The total amount of domperidone excreted into breast milk is less than 7 μg / day when the maximum permissible doses are applied. It is not known whether this level has a negative effect on newborns. Therefore, if you need to use the drug Motilium during lactation, breastfeeding should be discontinued.

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Allopurinol (Embarin).
Active Ingredient: Allopurinol.

Allopurinol is a drug that has anti-gout effect on the body and helps to reduce the concentration of uric acid.

Analog: Zyloprim.

Other names for this medication: Adenock, Aideito, Alfadiman, Allo, Allo-puren, Allobenz, Allobeta, Allohexal, Allopim, Alloprim, Allopur, Allopurin, Allopurinolo, Allopurinolum, Allozym, Allural, Allurit, Aloprim, Alopurinol, Aloral, Alositol, Aluline, Apo-allopurinol, Apurin, Apurol, Atisuril, Bleminol, Caplenal, Capurate, Cellidrin, Cosuric, Dabroson, Darzune, Embarin, Epidropal, Etindrax, Foligan, Geapur, Gichtex, Hamarin, Lopurin, Lysuron, Masaton, Mephanol, Milurit, Progout, Remid, Riball, Rimapurinol, Sigapurol, Suspendol, Urbol, Uredimin, Uribenz, Uricemil, ürikoliz, Uripurinol, Uriscel, Urobenyl, Urosin, Urtias, Vedatan, Xanthomax, Zylol, Zyloric

Form of the preparation
The drug Allopurinol is available in the form of coated tablets, with a dosage of 100 and 300 mg.

Pharmacological properties of the drug
Tablets Allopurinol when ingested contribute to the dissolution of urate stones and reduce the concentration of urea in the body.

When taking a single dose, the maximum concentration of the main active ingredient, allopurinol, in serum is reached after 5 hours. The active substance of the drug quickly breaks down into metabolic products, and some of it is eliminated naturally through the kidneys.

Indications for use of the drug
▶ The main indications for the use of Allopurinol pills are the following:

✧ An increased concentration of uric acid in the blood serum – this condition is checked by means of blood tests that are given up on an empty stomach;
✧ Identified stones and sand in the urinary tract and kidneys – the drug is shown only if the stone does not overlap the ureter, and its size does not exceed 2 mm in diameter;
✧ Gout;
✧ Disorders of metabolic processes in the body, namely purines and pyrimidines;
✧ As part of complex therapy for acute and chronic myeloid leukemia;
✧ In the complex treatment of acute leukemia;
✧ In the complex treatment of lymphosarcoma;
✧ Psoriasis;
✧ Numerous injuries and pathologies of the motor apparatus, which can lead to numerous violations of metabolic processes in the body;
✧ Side effects that develop in the patient as a result of prolonged or uncontrolled treatment with glucocorticoids or their analogues of synthetic origin;
✧ After the passed course of chemotherapy of cancers in order to prevent the formation of urate stones in the organs of urination.

Before using this medication, you should carefully read the instructions.

▶ Allopurinol therapy is categorically contraindicated in the following conditions:

Individual intolerance to the components of the drug;
Age to 15 years;
Hepatic or renal insufficiency in the stage of decompensation;
The period of breastfeeding or pregnancy.

Dosing and Administration
Tablets Allopurinol should be taken orally, without chewing after eating. For each individual patient, the doctor sets the optimal and effective dose, which directly depends on his diagnosis, body weight, age and the presence of concomitant pathologies. The average daily norm of the drug for an adult is from 100 to 900 mg. The number of appointments per day is determined by the doctor, but, as a rule, the tablets should be taken 2-3 times a day at regular intervals.

In pediatric practice, this drug is not used, except for persons under 15 years who undergo treatment for cancer, and they develop severe metabolic disorders, accompanied by an increased content of uric acid in the body.

Side effects
In most cases, this drug is well tolerated by the patient, provided that they accurately observe the dosage indicated by the doctor. Sometimes the patient may develop side effects during treatment with Allopurinol, which are manifested by the following symptoms:

✦ On the part of the organs of the digestive system – abdominal pain, diarrhea, vomiting, nausea, excessive salivation, inflammation of the liver and its increase in size, the development of ulcers in the oral cavity;
✦ From the side of the cardiovascular system – slowing down the number of heart beats a minute, increasing blood pressure, feeling that the patient is now suffocating;
✦ From the side of the central nervous system – increasing weakness, severe headaches or dizziness, depression and depression, apathy to what is happening, inhibition, drowsiness, decreased visual acuity;
From the side of the urinary and genital system – the development of inflammatory processes of the kidney tissue, edema, uremia, a significant increase in the number of erythrocytes in the urine, resulting in a reddish color, difficulties with the onset of conception, gynecomastia in men – breast enlargement, erectile dysfunction;
✦ From the hematopoietic system – a decrease in the number of platelets in the blood test, the development of aplastic anemia, a decrease in the number of leukocytes;
✦ Allergic reactions – the appearance of rashes on the skin, itching of the skin, increased body temperature, not caused by cold or infectious diseases, pain in the joints, redness of the skin;
Development of alopecia;
The appearance of boils at different parts of the body.

Special instructions
Allopurinol tablets should be given with special caution to patients who have impaired thyroid function or other endocrine system function. In addition, the tablets of this drug with caution should be taken in patients with severe impairment of kidney and liver.

During the period of treatment with this drug, the patient must closely monitor the daily amount of fluid used, which is at least 2 liters.

During the course of therapy with allopurinol, care should be taken to manage the transport, since the influence of the active substances on the central nervous system may slightly suppress or slow down the reaction rate.

Allopurinol and alcoholic drinks are absolutely incompatible, therefore, during the period of drug use, it is strictly forbidden to drink alcohol.

Storage, dispensing and shelf life of the preparation
Tablets should be stored in a dark, cool place out of the reach of children. Shelf life of the drug is 3 years from the date of manufacture, which is indicated on the package. Allopurinol is dispensed in pharmacies without a prescription.

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 Bentyl (Dicyclomine).

♻Description of the active substance Dicyclomine / Dicyclomine.
Formula: C19H35NO2, the chemical name: 1-cyclohexylcyclohexanecarboxylic acid, beta- (diethylamino) ethyl ether (as hydrochloride).

♻Pharmacological group: vegetotrophic agents / cholinolytic agents / m-cholinolytics; organotropic agents / antispasmodic myotropic.

♻Pharmacological action: myotropic, anticholinergic, spasmolytic.

Dicyclomine is known as dicycloverine hydrochloride hydrochloride. Dicycloverin contains 72 percent of the anti-muscarinic effect of atropine. It was invented in the USA in 1947.

Clinical use
Dicyclomine is used to treat intestinal mobility, symptoms of irritable bowel syndrome (also known as colonic spasms).
It relieves muscle spasms and spasms in the gastrointestinal tract, blocking the activity of acetylcholine on cholinergic (or muscarinic) receptors on the surface of muscle cells (smooth muscle relaxant).
Its effectiveness as a drug against incontinence is investigated.

Oral: The initial dose of 80 mg / day (4 equal doses) is reported to be 160 mg / day.
Intramuscularly: 20 mg 4 times a day.
Intravenously: Not used.

Side effects
Dicyclomine can cause a variety of anticholinergic side effects, such as dry mouth, nausea.
In some cases, there is a state of euphoria and arousal, premature death (death) after taking more than 10 tablets at a time.

Irritable Bowel Syndrome (IBS) is a common disease affecting 10-15% of the adult population. Its causes are unknown, and the symptoms can be very different and include abdominal pain, bloating and flatulence, constipation or diarrhea. Preparations from irritable bowel syndrome can not completely cure the patient, but they can significantly alleviate the symptoms.

Medications from this group have antispasmodic properties, that is, they suppress contractions of the smooth muscles of the intestine. These drugs help alleviate the symptoms of abdominal cramps in irritable bowel syndrome.

Dicyclomine (Bentyl)
This drug directly relaxes the smooth muscles of the intestine, without affecting the production of gastric acid. Its effect begins 1-2 hours after taking and lasts up to 4 hours. Dicyclomine is taken orally, as a rule – 4 times a day before meals and at night.

To prevent the development of side effects, the doctor can first prescribe this remedy in small amounts, and then gradually increase the dose. Antacids reduce the absorption of dicyclomine, so it can not be taken simultaneously with it.

If you take this medicine for the treatment of irritable bowel syndrome regularly enough and for a long time, with a sudden discontinuation of its reception, withdrawal can occur, which is manifested by dizziness, sweating and vomiting.

Other side effects that may occur with the use of dicyclomine:
☞ dizziness (40%);
☞ dry mouth (33%);
☞ blurred vision (27%);
☞ drowsiness (9%);
☞ nervousness (6%);
☞ general weakness (7%).

Less frequent abdominal distention, confusion, paralysis of accommodation, delirium, dermatitis, erythema, fatigue, hallucinations, insomnia, malaise, palpitation, rashes, syncope.

⚠This drug for the treatment of irritable bowel syndrome can not be used concomitantly with alcohol⚠

Dicyclomine is contraindicated in:

➡allergies to it or other anticholinergics;
➡angle-closure glaucoma;
➡myasthenia gravis;
➡massive bleeding;
➡atony of the intestine;
➡toxic megacolon;
➡intestinal obstruction;
➡severe ulcerative colitis;
➡reflux with esophagitis.

Also, it is not used in women breastfeeding, and in children younger than 6 months.

With care, dicyclomine is prescribed:
⇨ patients with hepatic or renal insufficiency;
⇨ patients with benign prostatic hyperplasia;
⇨ people with congestive heart failure;
⇨ with tachycardia due to heart failure or thyrotoxicosis, arterial hypertension, ischemic heart disease, chronic obstructive pulmonary disease, mitral stenosis, brain damage;
⇨ with tachyarrhythmia.

♻Other names for this medication:
Algermin, Bentylol, Berclomine, Byclomine, Colchimax, Colicon, Colimix,  Cosaichill, Cyclominol, Cyclopam, Cyclopan, Cymine, Dibent, Diciclomina,  Dicicloverina, Dicomin, Dicycloverin, Dicycloverine, Dicycloverinum,  Dicymine, Difemic, Formulex, Kolantyl, Loverin,  Magesanp,  Mainnox, Merbentyl, Notensyl, Or-tyl, Relestal, Resporix, Trigan.