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 Bentyl (Dicyclomine)

♻Description of the active substance Dicyclomine / Dicyclomine.
Formula: C19H35NO2, the chemical name: 1-cyclohexylcyclohexanecarboxylic acid, beta- (diethylamino) ethyl ether (as hydrochloride).

♻Pharmacological group: vegetotrophic agents / cholinolytic agents / m-cholinolytics; organotropic agents / antispasmodic myotropic.

♻Pharmacological action: myotropic, anticholinergic, spasmolytic.

Dicyclomine is known as dicycloverine hydrochloride hydrochloride. Dicycloverin contains 72 percent of the anti-muscarinic effect of atropine. It was invented in the USA in 1947.

Clinical use
Dicyclomine is used to treat intestinal mobility, symptoms of irritable bowel syndrome (also known as colonic spasms).
It relieves muscle spasms and spasms in the gastrointestinal tract, blocking the activity of acetylcholine on cholinergic (or muscarinic) receptors on the surface of muscle cells (smooth muscle relaxant).
Its effectiveness as a drug against incontinence is investigated.

Dosage:
Oral: The initial dose of 80 mg / day (4 equal doses) is reported to be 160 mg / day.
Intramuscularly: 20 mg 4 times a day.
Intravenously: Not used.

Side effects
Dicyclomine can cause a variety of anticholinergic side effects, such as dry mouth, nausea.
In some cases, there is a state of euphoria and arousal, premature death (death) after taking more than 10 tablets at a time.

Irritable Bowel Syndrome (IBS) is a common disease affecting 10-15% of the adult population. Its causes are unknown, and the symptoms can be very different and include abdominal pain, bloating and flatulence, constipation or diarrhea. Preparations from irritable bowel syndrome can not completely cure the patient, but they can significantly alleviate the symptoms.

Anticholinergics
Medications from this group have antispasmodic properties, that is, they suppress contractions of the smooth muscles of the intestine. These drugs help alleviate the symptoms of abdominal cramps in irritable bowel syndrome.

Dicyclomine (Bentyl)
This drug directly relaxes the smooth muscles of the intestine, without affecting the production of gastric acid. Its effect begins 1-2 hours after taking and lasts up to 4 hours. Dicyclomine is taken orally, as a rule – 4 times a day before meals and at night.

To prevent the development of side effects, the doctor can first prescribe this remedy in small amounts, and then gradually increase the dose. Antacids reduce the absorption of dicyclomine, so it can not be taken simultaneously with it.

If you take this medicine for the treatment of irritable bowel syndrome regularly enough and for a long time, with a sudden discontinuation of its reception, withdrawal can occur, which is manifested by dizziness, sweating and vomiting.

Other side effects that may occur with the use of dicyclomine:
☞ dizziness (40%);
☞ dry mouth (33%);
☞ blurred vision (27%);
☞ drowsiness (9%);
☞ nervousness (6%);
☞ general weakness (7%).

Less frequent abdominal distention, confusion, paralysis of accommodation, delirium, dermatitis, erythema, fatigue, hallucinations, insomnia, malaise, palpitation, rashes, syncope.

⚠This drug for the treatment of irritable bowel syndrome can not be used concomitantly with alcohol⚠

Dicyclomine is contraindicated in:

➡allergies to it or other anticholinergics;
➡angle-closure glaucoma;
➡myasthenia gravis;
➡massive bleeding;
➡atony of the intestine;
➡toxic megacolon;
➡intestinal obstruction;
➡severe ulcerative colitis;
➡reflux with esophagitis.

Also, it is not used in women breastfeeding, and in children younger than 6 months.

With care, dicyclomine is prescribed:
⇨ patients with hepatic or renal insufficiency;
⇨ patients with benign prostatic hyperplasia;
⇨ people with congestive heart failure;
⇨ with tachycardia due to heart failure or thyrotoxicosis, arterial hypertension, ischemic heart disease, chronic obstructive pulmonary disease, mitral stenosis, brain damage;
⇨ with tachyarrhythmia.

♻Other names for this medication:
Algermin, Bentylol, Berclomine, Byclomine, Colchimax, Colicon, Colimix,  Cosaichill, Cyclominol, Cyclopam, Cyclopan, Cymine, Dibent, Diciclomina,  Dicicloverina, Dicomin, Dicycloverin, Dicycloverine, Dicycloverinum,  Dicymine, Difemic, Formulex, Kolantyl, Loverin,  Magesanp,  Mainnox, Merbentyl, Notensyl, Or-tyl, Relestal, Resporix, Trigan

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